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PMID:23559745
| Citation |
Wu, X, Gong, F and Wang, W (2013) Functional assignment to maize group 1 LEA protein EMB564 within the cell nucleus using computational analysis. Bioinformation 9:276-80 |
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| Abstract |
Maize protein EMB564 is a member of group 1 LEA (late embryogenesis abundant) proteins. Currently, the molecular functions of group 1 LEA proteins remain largely unclear. We here report on the functional assignment to EMB564 by computational analysis. EMB564 is predicted as nuclear localization by five different predictors including CELLO, Plant-mPLoc, WoLF PSORT, Predotar and TargetP. EMB564 is found to be remote homologous with DNA/RNA helicases and single-stranded DNA-binding proteins, and their sequences contains similar DNA/RNA binding sites. Furthermore, the three-dimensional (3D) model of EMB564 structurally resembles a variety of nuclear and DNA/RNA-binding proteins, especially those involving in the regulation of cell division, chromosomal replication and DNA unwinding or repairing. Our results reveal that EMB564 protein is most likely to function within the cell nucleus. |
| Links |
PubMed PMC3607185 Online version:10.6026/97320630009276 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677: DNA binding |
ECO:0000255: |
PMID:16845003[1] PMID:17237068[2]
|
F |
Figure 1A, parts a and b |
complete | |||
|
enables |
GO:0003677: DNA binding |
ECO:0000255: match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
See also
References
See Help:References for how to manage references in GONUTS.
- ↑ Wang, L & Brown, SJ (2006) BindN: a web-based tool for efficient prediction of DNA and RNA binding sites in amino acid sequences. Nucleic Acids Res. 34 W243-8 PubMed GONUTS page
- ↑ Hwang, S et al. (2007) DP-Bind: a web server for sequence-based prediction of DNA-binding residues in DNA-binding proteins. Bioinformatics 23 634-6 PubMed GONUTS page
