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PMID:23536551
| Citation |
Ditkowski, B, Holmes, N, Rydzak, J, Donczew, M, Bezulska, M, Ginda, K, Kedzierski, P, Zakrzewska-Czerwinska, J, Kelemen, GH and Jakimowicz, D (2013) Dynamic interplay of ParA with the polarity protein, Scy, coordinates the growth with chromosome segregation in Streptomyces coelicolor. Open Biol 3:130006 |
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| Abstract |
Prior to bacterial cell division, the ATP-dependent polymerization of the cytoskeletal protein, ParA, positions the newly replicated origin-proximal region of the chromosome by interacting with ParB complexes assembled on parS sites located close to the origin. During the formation of unigenomic spores from multi-genomic aerial hyphae compartments of Streptomyces coelicolor, ParA is developmentally triggered to form filaments along the hyphae; this promotes the accurate and synchronized segregation of tens of chromosomes into prespore compartments. Here, we show that in addition to being a segregation protein, ParA also interacts with the polarity protein, Scy, which is a component of the tip-organizing centre that controls tip growth. Scy recruits ParA to the hyphal tips and regulates ParA polymerization. These results are supported by the phenotype of a strain with a mutant form of ParA that uncouples ParA polymerization from Scy. We suggest that the ParA-Scy interaction coordinates the transition from hyphal elongation to sporulation. |
| Links |
PubMed Online version:10.1098/rsob.130006 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0030427: site of polarized growth |
ECO:0000316: |
UniProtKB:F8JJL5
|
C |
Figure 1a shows ParA interacting with Scy in Bacterial Two Hybrid system. |
complete | |||
See also
References
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