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PMID:23469015
| Citation |
Vadhvani, M, Schwedhelm-Domeyer, N, Mukherjee, C and Stegmüller, J (2013) The Centrosomal E3 Ubiquitin Ligase FBXO31-SCF Regulates Neuronal Morphogenesis and Migration. PLoS ONE 8:e57530 |
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| Abstract |
Neuronal development requires proper migration, polarization and establishment of axons and dendrites. Growing evidence identifies the ubiquitin proteasome system (UPS) with its numerous components as an important regulator of various aspects of neuronal development. F-box proteins are interchangeable subunits of the Cullin-1 based E3 ubiquitin ligase, but only a few family members have been studied. Here, we report that the centrosomal E3 ligase FBXO31-SCF (Skp1/Cullin-1/F-box protein) regulates neuronal morphogenesis and axonal identity. In addition, we identified the polarity protein Par6c as a novel interaction partner and substrate targeted for proteasomal degradation in the control of axon but not dendrite growth. Finally, we ascribe a role for FBXO31 in dendrite growth and neuronal migration in the developing cerebellar cortex. Taken together, we uncovered the centrosomal E3 ligase FBXO31-SCF as a novel regulator of neuronal development. |
| Links |
PubMed Online version:10.1371/journal.pone.0057530 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005813: centrosome |
ECO:0000314: |
C |
Figure 1A |
complete | ||||
| GO:0050775: positive regulation of dendrite morphogenesis |
ECO:0000315: |
P |
Figure 6B and 6C |
complete | ||||
| GO:2001224: positive regulation of neuron migration |
ECO:0000315: |
P |
figure 6F |
complete | ||||
|
part_of |
GO:0005813: centrosome |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050775: positive regulation of dendrite morphogenesis |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001224: positive regulation of neuron migration |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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