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PMID:23459485
| Citation |
Tada, T, Miyoshi-Akiyama, T, Dahal, RK, Sah, MK, Ohara, H, Kirikae, T and Pokhrel, BM (2013) NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal. Antimicrob. Agents Chemother. 57:2394-6 |
|---|---|
| Abstract |
A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1. |
| Links |
PubMed PMC3632942 Online version:10.1128/AAC.02553-12 |
| Keywords |
Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Bacterial Typing Techniques; Base Sequence; Drug Resistance, Multiple, Bacterial/drug effects; Drug Resistance, Multiple, Bacterial/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/isolation & purification; Escherichia coli Infections/drug therapy; Escherichia coli Infections/microbiology; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Nepal; RNA, Ribosomal, 16S/genetics; beta-Lactamases/genetics; beta-Lactamases/metabolism; beta-Lactams/metabolism; beta-Lactams/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008800: beta-lactamase activity |
ECO:0000314: |
F |
Table 2 shows the kinetic data for hydrolysis of beta-lactam antibiotics by purified NDM-8 |
complete | ||||
|
enables |
GO:0008800: beta-lactamase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
Notes
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