PMID:23312593

Citation	Alibardi, L and Bernd, N' (2013) Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins. Acta Histochem. '
Abstract	The inner root sheath (IRS) sustains and addresses the hair shaft outside the follicle. Ultrastructural analysis of immunolabeling for beta-catenin, plakophilin-1, desmoglein-4 and keratin-17 in human hairs has indicated that adherens junctions and desmosomes initially connect cells in mature IRS and the companion layer. Beta-catenin immunolabeling for adherens junctions is only seen in sparse regions of differentiating Huxley cells, Flugelzellen cells and Henle cells, but disappears in cornified cells of the IRS. Desmoglein-4 and plakophilin-1 immunolabeling are observed in differentiating and cornified desmosomes of the Huxley and Henle layers and in the membrane complex joining these cells. Desmoglein-4 and plakophilin-1 are more frequently immunolocalized in the intracellular side of the junctions, but some labeling is also present in the delta-layer of the membrane complex. The labeling indicates a prevalent intracellular redistribution of desmoglein-4 and plakophilin-1 when the final cornification of the IRS occurs. Intense keratin-17 immunolabeling is observed in tonofilaments of the companion layer joining the plakophilin-1 rich desmosomes of the Henle layer. This suggests that this elastic type of keratin is present at desmosome junctions during the movements of the companion layer along the slippage plane of the hair shaft.
Links	PubMed Online version:10.1016/j.acthis.2012.11.011
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