PMID:23289018

Citation	Jiang, X, Yue, J, Lu, H, Campbell, N, Yang, Q, Lan, S, Haffty, BG, Yuan, C and Shen, Z (2013) Inhibition of filamin-A reduces cancer metastatic potential. Int. J. Biol. Sci. 9:67-77
Abstract	Filamin-A cross-links actin filaments into dynamic orthogonal networks, and interacts with an array of proteins of diverse cellular functions. Because several filamin-A interaction partners are implicated in signaling of cell mobility regulation, we tested the hypothesis that filamin-A plays a role in cancer metastasis. Using four pairs of filamin-A proficient and deficient isogenic cell lines, we found that filamin-A deficiency in cancer cells significantly reduces their migration and invasion. Using a xenograft tumor model with subcutaneous and intracardiac injections of tumor cells, we found that the filamin-A deficiency causes significant reduction of lung, splenic and systemic metastasis in nude mice. We evaluated the expression of filamin-A in breast cancer tissues by immunohistochemical staining, and found that low levels of filamin-A expression in cancer cells of the tumor tissues are associated with a better distant metastasis-free survival than those with normal levels of filamin-A. These data not only validate filamin-A as a prognostic marker for cancer metastasis, but also suggest that inhibition of filamin-A in cancer cells may reduce metastasis and that filamin-A can be used as a therapeutic target for filamin-A positive cancer.
Links	PubMed PMC3535535 Online version:10.7150/ijbs.5577
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:FLNA		GO:0030335: positive regulation of cell migration	ECO:0000315:		P		Figure 1 and 2 show that inhibition of Filamin-a leads to decreased cell migration.	complete CACAO 7041

References

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