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PMID:23212337
| Citation |
Yan, S, Li, YZ, Zhu, JW, Liu, CL, Wang, P and Liu, YL (2012) Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis. Genet. Mol. Res. 11:3998-4007 |
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| Abstract |
We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529 T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529 T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer. |
| Links |
PubMed Online version:10.4238/2012.November.26.1 |
| Keywords |
Case-Control Studies; Caspase 10/genetics; Genetic Predisposition to Disease; Genome, Human/genetics; Humans; Linear Models; Neoplasms/epidemiology; Neoplasms/genetics; Odds Ratio; Polymorphism, Single Nucleotide/genetics; Publication Bias |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
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