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Keller, LE, Jones, CV, Thornton, JA, Sanders, ME, Swiatlo, E, Nahm, MH, Park, IH and McDaniel, LS (2013) PspK of Streptococcus pneumoniae increases adherence to epithelial cells and enhances nasopharyngeal colonization. Infect. Immun. 81:173-81


Streptococcus pneumoniae (the pneumococcus) colonizes the human nasopharynx and can cause invasive disease aided by the pneumococcal capsule. Group II nontypeable S. pneumoniae (NTSp) lacks a polysaccharide capsule, and a subgroup of NTSp carriage isolates has been found to have a novel gene, pneumococcal surface protein K (pspK), which replaces the capsule locus. A recent rise in the number of NTSp isolates colonizing the human nasopharynx has been observed, but the colonization factors of NTSp have not been well studied. PspK has been shown to play a role in mouse colonization. We therefore examined PspK-mediated immune evasion along with adherence to host cells and colonization. PspK bound human secretory immunoglobulin A (sIgA) but not the complement regulator factor H and did not decrease C3b deposition on the pneumococcal surface. PspK increased binding of pneumococci to epithelial cells and enhanced pneumococcal colonization independently of the genetic background. Understanding how NTSp colonizes and survives within the nasopharynx is important due to the increase in NTSp carriage. Our data suggest that PspK may aid in the persistence of NTSp within the nasopharynx but is not involved in invasion.


PubMed PMC3536125 Online version:10.1128/IAI.00755-12


Animals; Antigens, Surface/immunology; Antigens, Surface/metabolism; Bacterial Adhesion/immunology; Bacterial Proteins/immunology; Bacterial Proteins/metabolism; Cell Line; Complement C3b/immunology; Complement C3b/metabolism; Complement Factor H/immunology; Complement Factor H/metabolism; Epithelial Cells/immunology; Epithelial Cells/metabolism; Epithelial Cells/microbiology; Humans; Immunoglobulin A, Secretory/immunology; Immunoglobulin A, Secretory/metabolism; Mice; Mice, Inbred C57BL; Nasopharynx/immunology; Nasopharynx/microbiology; Pneumococcal Infections/immunology; Pneumococcal Infections/metabolism; Pneumococcal Infections/microbiology; Streptococcus pneumoniae/cytology; Streptococcus pneumoniae/immunology; Streptococcus pneumoniae/metabolism



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status


GO:0044651: adhesion of symbiont to host epithelial cell



Figure 4

CACAO 12165


See also


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