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PMID:23049841
| Citation |
Peñalosa-Ruiz, G, Aranda, C, Ongay-Larios, L, Colon, M, Quezada, H and Gonzalez, A (2012) Paralogous ALT1 and ALT2 Retention and Diversification Have Generated Catalytically Active and Inactive Aminotransferases in Saccharomyces cerevisiae. PLoS ONE 7:e45702 |
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| Abstract |
Gene duplication and the subsequent divergence of paralogous pairs play a central role in the evolution of novel gene functions. S. cerevisiae possesses two paralogous genes (ALT1/ALT2) which presumably encode alanine aminotransferases. It has been previously shown that Alt1 encodes an alanine aminotransferase, involved in alanine metabolism; however the physiological role of Alt2 is not known. Here we investigate whether ALT2 encodes an active alanine aminotransferase. |
| Links |
PubMed PMC3458083 Online version:10.1371/journal.pone.0045702 |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
References
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