GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:23007066
| Citation |
Unno, T, Matsumoto, Y and Yamamoto, Y (2012) Gallated form of tea catechin, not nongallated form, increases fecal starch excretion in rats. J. Nutr. Sci. Vitaminol. 58:45-9 |
|---|---|
| Abstract |
This study was carried out to elucidate the structural advantage of a gallated form of tea catechin on modulating bioavailability of dietary starch in rats. Animal studies demonstrated that the addition of 0.5% (w/w) (-)-epigallocatechin gallate (EGCG) to the diet brought about a significant increase in the starch content in the feces collected for 2 d at the fourth week of feeding over that with the control diet. Of the gross starch that the rats consumed from their respective diets during the fecal collection period, 0.1% (for control diet) and 1.9% (for EGCG diet) were estimated to be excreted in the feces. However, such a significant increase in the fecal excretion of starch by the EGCG diet was lost by undergoing hydrolysis of EGCG to (-)-epigallocatechin (EGC) and gallic acid (GA). In vitro investigation also showed that EGCG inhibited porcine pancreatic α-amylase activity in a concentration-dependent fashion, whereas the hydrolyzed preparation (the mixture of EGC and GA) exhibited a lack of the inhibitory activity for α-amylase. The modification of dietary starch digestion by inhibiting intestinal α-amylase activity with EGCG may be responsible at least in part for increasing fecal output of starch in rats. Thus, the attachment of a galloyl moiety to the tea flavan-3-ol skeleton may be of key importance for reducing intestinal digestion of dietary starch in rats. |
| Links | |
| Keywords |
|
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0004556: alpha-amylase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004556: alpha-amylase activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0004556: alpha-amylase activity |
ECO:0000315: |
F |
Figure 2 |
complete | ||||
| GO:0004556: alpha-amylase activity |
ECO:0000314: |
F |
Figure 2 |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
