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PMID:22962598
| Citation |
Rah, B, Amin, H, Yousuf, K, Khan, S, Jamwal, G, Mukherjee, D and Goswami, A (2012) A novel MMP-2 inhibitor 3-azidowithaferin A (3-azidoWA) abrogates cancer cell invasion and angiogenesis by modulating extracellular Par-4. PLoS ONE 7:e44039 |
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| Abstract |
Withaferin A, which is a naturally derived steroidal lactone, has been found to prevent angiogenesis and metastasis in diverse tumor models. It has also been recognized by different groups for prominent anti-carcinogenic roles. However, in spite of these studies on withanolides, their detailed anti-metastatic mechanism of action remained unknown. The current study has poised to address the machinery involved in invasion regulation by stable derivative of Withaferin A, 3-azido Withaferin A (3-azidoWA) in human cervical HeLa and prostate PC-3 cells. |
| Links |
PubMed PMC3433490 Online version:10.1371/journal.pone.0044039 |
| Keywords |
Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Azides/chemical synthesis; Azides/pharmacology; Biological Assay; Cell Line, Tumor; Cell Movement/drug effects; Collagen; Drug Combinations; Extracellular Signal-Regulated MAP Kinases/genetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Gene Expression Regulation, Neoplastic; Humans; Laminin; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase Inhibitors/chemical synthesis; Matrix Metalloproteinase Inhibitors/pharmacology; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness/prevention & control; Neovascularization, Pathologic/prevention & control; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Receptors, Thrombin/antagonists & inhibitors; Receptors, Thrombin/genetics; Receptors, Thrombin/metabolism; Signal Transduction; Withanolides/chemical synthesis; Withanolides/pharmacology |
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