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PMID:22905678
| Citation |
Du, XY, Huang, J, Xu, LQ, Tang, DF, Wu, L, Zhang, LX, Pan, XL, Chen, WY, Zheng, LP and Zheng, YH (2012) The proto-oncogene c-src is involved in primordial follicle activation through the PI3K, PKC and MAPK signaling pathways. Reprod. Biol. Endocrinol. 10:58 |
|---|---|
| Abstract |
C-src is an evolutionarily conserved proto-oncogene that regulates cell proliferation, differentiation and apoptosis. In our previous studies, we have reported that another proto-oncogene, c-erbB2, plays an important role in primordial follicle activation and development. We also found that c-src was expressed in mammalian ovaries, but its functions in primordial follicle activation remain unclear. The objective of this study is to investigate the role and mechanism of c-src during the growth of primordial follicles. |
| Links |
PubMed PMC3444437 Online version:10.1186/1477-7827-10-58 |
| Keywords |
Animals; Animals, Newborn; Chromones/pharmacology; Enzyme Inhibitors/pharmacology; Female; Genes, src/physiology; MAP Kinase Signaling System/physiology; Morpholines/pharmacology; Organ Culture Techniques; Ovarian Follicle/enzymology; Ovarian Follicle/growth & development; Ovarian Follicle/metabolism; Phosphatidylinositol 3-Kinases/antagonists & inhibitors; Phosphatidylinositol 3-Kinases/physiology; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/physiology; Rats; Rats, Sprague-Dawley; Signal Transduction/physiology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0001545: primary ovarian follicle growth |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020: membrane |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000386: positive regulation of ovarian follicle development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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