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PMID:22792309
| Citation |
Zhang, Y, Xu, J, Wang, Z, Zhang, X, Liang, X and Civelli, O (2012) BmK-YA, an enkephalin-like peptide in scorpion venom. PLoS ONE 7:e40417 |
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| Abstract |
By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor that displays a signal sequence and contains four copies of BmK-YA sequences and four of His(4)-BmK-YA, all flanked by single amino acid residues. BmK-YA and His(4)-BmK-YA are amidated and thus fulfill the characteristics expected of bioactive peptides. BmK-YA can activate mammalian opioid receptors with selectivity for the δ subtype while His(4)-BmK-YA is inactive at opioid receptors. The discovery of BmK-YA suggests that scorpion venom may represent a novel source of bioactive molecules targeting G protein-coupled receptors (GPCRs) and reveal additional insights on the evolution of the opioid precursors. |
| Links |
PubMed PMC3392217 Online version:10.1371/journal.pone.0040417 |
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Significance
Annotations
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See also
References
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