GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:22748812
| Citation |
Häuser, R, Blasche, S, Dokland, T, Haggård-Ljungquist, E, von Brunn, A, Salas, M, Casjens, S, Molineux, I and Uetz, P (2012) Bacteriophage protein-protein interactions. Adv. Virus Res. 83:219-98 |
|---|---|
| Abstract |
Bacteriophages T7, λ, P22, and P2/P4 (from Escherichia coli), as well as ϕ29 (from Bacillus subtilis), are among the best-studied bacterial viruses. This chapter summarizes published protein interaction data of intraviral protein interactions, as well as known phage-host protein interactions of these phages retrieved from the literature. We also review the published results of comprehensive protein interaction analyses of Pneumococcus phages Dp-1 and Cp-1, as well as coliphages λ and T7. For example, the ≈55 proteins encoded by the T7 genome are connected by ≈43 interactions with another ≈15 between the phage and its host. The chapter compiles published interactions for the well-studied phages λ (33 intra-phage/22 phage-host), P22 (38/9), P2/P4 (14/3), and ϕ29 (20/2). We discuss whether different interaction patterns reflect different phage lifestyles or whether they may be artifacts of sampling. Phages that infect the same host can interact with different host target proteins, as exemplified by E. coli phage λ and T7. Despite decades of intensive investigation, only a fraction of these phage interactomes are known. Technical limitations and a lack of depth in many studies explain the gaps in our knowledge. Strategies to complete current interactome maps are described. Although limited space precludes detailed overviews of phage molecular biology, this compilation will allow future studies to put interaction data into the context of phage biology. |
| Links |
PubMed PMC3461333 Online version:10.1016/B978-0-12-394438-2.00006-2 |
| Keywords |
Bacillus Phages/physiology; Bacillus subtilis/virology; Coliphages/physiology; Escherichia coli/virology; Host-Parasite Interactions; Protein Binding; Protein Interaction Mapping; Streptococcus Phages/physiology; Streptococcus pneumoniae/virology; Viral Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
See also
References
See Help:References for how to manage references in GONUTS.
