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PMID:22476771
| Citation |
Lone, SR and Sharma, VK (2012) Or47b receptor neurons mediate sociosexual interactions in the fruit fly Drosophila melanogaster. J. Biol. Rhythms 27:107-16 |
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| Abstract |
In the fruit fly Drosophila melanogaster, social interactions especially among heterosexual couples have been shown to have significant impact on the circadian timing system. Olfaction plays a major role in such interactions; however, we do not know yet specifically which receptor(s) are involved. Further, the role of circadian clock neurons in the rhythmic regulation of such sociosexual interactions (SSIs) is not fully understood. Here, we report the results of our study in which we assayed the locomotor activity and sleep-wake behaviors of male-male (MM), female-female (FF), and male-female (MF) couples from several wild-type and mutant strains of Drosophila with an aim to identify specific olfactory receptor(s) and circadian clock neurons involved in the rhythmic regulation of SSI. The results indicate that Or47b receptor neurons are necessary for SSI, as ablation or silencing of these neurons has a severe impact on SSI. Further, the neuropeptide pigment dispersing factor (PDF) and PDF-positive ventral lateral (LN(v)) clock neurons appear to be dispensable for the regulation of SSI; however, dorsal neurons may be involved. |
| Links |
PubMed Online version:10.1177/0748730411434384 |
| Keywords |
Analysis of Variance; Animals; Biological Clocks/physiology; Circadian Rhythm/physiology; Cryptochromes/genetics; Cryptochromes/metabolism; Cryptochromes/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Drosophila melanogaster/physiology; Female; Male; Motor Activity/physiology; Mutation; Neurons/metabolism; Neurons/physiology; Olfactory Bulb/metabolism; Olfactory Bulb/physiology; Receptors, Odorant/genetics; Receptors, Odorant/metabolism; Receptors, Odorant/physiology; Sexual Behavior, Animal/physiology; Sleep/physiology; Smell; Social Behavior |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0007608: sensory perception of smell |
ECO:0000314: |
P |
Figure 2 demonstrates sociosexual interactions are olfactory mediated based on the activity data of MF, MM, and FF couples. Figure 3 reveals the decrease in SSI of Or47b-ablated flies. The SSI activity of males is shown to be dependent on olfactory senses according to Figure 4. |
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