PMID:22461610

Citation	Rogulja, D and Young, MW (2012) Control of sleep by cyclin A and its regulator. Science 335:1617-21
Abstract	How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.
Links	PubMed PMC3380085 Online version:10.1126/science.1212476
Keywords	Animals; Brain/cytology; Brain/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Circadian Clocks; Cyclin A/genetics; Cyclin A/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Female; Genes, Insect; Homeostasis; Male; Neurons/metabolism; Neuropeptides/genetics; Neuropeptides/metabolism; Period Circadian Proteins/genetics; Period Circadian Proteins/metabolism; Phenotype; RNA Interference; Sleep/physiology; Sleep Deprivation
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Significance

Gene product

Qualifier

GO Term

Evidence Code

with/from

Aspect

Extension

Notes

Status

Colocalizes with

GO:0042752: regulation of circadian rhythm

ECO:0000314:

P

Figure 4 Association of CycA neurons and circadian clock neurons in the brain

(C) In different regions of the brain, cells labeled for CycA and PER cluster and partially overlap or overlap

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