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PMID:22442668
| Citation |
Moreno, H, Tejero, H, de la Torre, JC, Domingo, E and Martín, V (2012) Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection. PLoS ONE 7:e32550 |
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| Abstract |
Lethal mutagenesis is a transition towards virus extinction mediated by enhanced mutation rates during viral genome replication, and it is currently under investigation as a potential new antiviral strategy. Viral load and virus fitness are known to influence virus extinction. Here we examine the effect or the multiplicity of infection (MOI) on progeny production of several RNA viruses under enhanced mutagenesis. |
| Links |
PubMed PMC3307711 Online version:10.1371/journal.pone.0032550 |
| Keywords |
Animals; Cercopithecus aethiops; Cricetinae; Genome, Viral/genetics; Mutagenesis; Mutation; RNA Virus Infections/genetics; RNA Virus Infections/metabolism; RNA Viruses/genetics; RNA Viruses/metabolism; Vero Cells; Viral Load |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
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