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PMID:22416675
| Citation |
Son, B, Yun, J, Lim, JA, Shin, H, Heu, S and Ryu, S (2012) Characterization of LysB4, an endolysin from the Bacillus cereus-infecting bacteriophage B4. BMC Microbiol. 12:33 |
|---|---|
| Abstract |
Bacillus cereus is a foodborne pathogen that causes emetic or diarrheal types of food poisoning. The incidence of B. cereus food poisoning has been gradually increasing over the past few years, therefore, biocontrol agents effective against B. cereus need to be developed. Endolysins are phage-encoded bacterial peptidoglycan hydrolases and have received considerable attention as promising antibacterial agents. |
| Links |
PubMed PMC3315420 Online version:10.1186/1471-2180-12-33 |
| Keywords |
Amino Acid Sequence; Bacillus Phages/enzymology; Bacillus Phages/genetics; Bacillus cereus/virology; Catalytic Domain; Cations, Divalent/metabolism; Coenzymes/metabolism; Computational Biology/methods; DNA, Viral/chemistry; DNA, Viral/genetics; Endopeptidases/chemistry; Endopeptidases/genetics; Endopeptidases/metabolism; Enzyme Stability; Hydrogen-Ion Concentration; Molecular Sequence Data; N-Acetylmuramoyl-L-alanine Amidase/chemistry; N-Acetylmuramoyl-L-alanine Amidase/genetics; N-Acetylmuramoyl-L-alanine Amidase/metabolism; Peptidoglycan/metabolism; Protein Structure, Tertiary; Sequence Analysis, DNA; Sequence Homology; Substrate Specificity; Temperature; Zinc/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004175: endopeptidase activity |
ECO:0000314: |
F |
Figure 4, data not shown. |
complete | ||||
| GO:0061786: peptidoglycan cross-bridge peptide endopeptidase activity |
ECO:0000314: |
F |
Figure 4 A and B. The specific LysB4 cleavage site in the peptidoglycan was determined by reverse-phase (RP)-HPLC and LC-MS. |
complete | ||||
Notes
See also
References
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