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PMID:22366109
| Citation |
Paik, D, Jang, YG, Lee, YE, Lee, YN, Yamamoto, R, Gee, HY, Yoo, S, Bae, E, Min, KJ, Tatar, M and Park, JJ (2012) Misexpression screen delineates novel genes controlling Drosophila lifespan. Mech. Ageing Dev. 133:234-45 |
|---|---|
| Abstract |
In an initial preliminary screen we identified factors associated with controlling Drosophila aging by examining longevity in adults where EP elements induced over-expression or antisense-RNA at genes adjacent to each insertion. Here, we study 45 EP lines that initially showed at least 10% longer mean lifespan than controls. These 45 lines and a daughterless (da)-Gal4 stock were isogenized into a CS10 wild-type background. Sixteen EP lines corresponding to 15 genes significantly extended lifespan when their target genes were driven by da-Gal4. In each case, the target genes were seen to be over-expressed. Independently derived UAS-gene transgenic stocks were available or made for two candidates: ImpL2 which is ecdysone-inducible gene L2, and CG33138, 1,4-alpha-glucan branching enzyme. With both, adult lifespan was increased upon over-expression via the GeneSwitch inducible Gal4 driver system. Several genes in this set of 15 correspond to previously discovered longevity assurance systems such as insulin/IGF-1 signaling, gene silencing, and autophagy; others suggest new potential mechanisms for the control of aging including mRNA synthesis and maturation, intracellular vesicle trafficking, and neuroendocrine regulation. |
| Links |
PubMed PMC3359393 Online version:10.1016/j.mad.2012.02.001 |
| Keywords |
1,4-alpha-Glucan Branching Enzyme/genetics; 1,4-alpha-Glucan Branching Enzyme/metabolism; Animals; Autophagy/genetics; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Enhancer Elements, Genetic; Female; Gene Expression Regulation; Longevity/genetics; Male; Promoter Regions, Genetic; Signal Transduction/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0008340: determination of adult lifespan |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0008340: determination of adult lifespan |
IMP: Inferred from Mutant Phenotype: |
P |
Seeded From UniProt |
complete |
| |||
See also
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