PMID:22311558

Citation	Lehman, W and Morgan, KG (2012) Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus. J. Muscle Res. Cell. Motil. 33:461-9
Abstract	The thin filaments of differentiated smooth muscle cells are composed of actin and tropomyosin isoforms and numerous ancillary actin-binding proteins that assemble together into distinct thin filament classes. These different filament classes are segregated in smooth muscle cells into structurally and functionally separated contractile and cytoskeletal cellular domains. Typically, thin filaments in smooth muscle cells have been considered to be relatively stable structures like those in striated cells. However, recent efforts have shown that smooth muscle thin filaments indeed are dynamic and that remodeling of the actin cytoskeleton, in particular, regulates smooth muscle function. Thus, the cytoskeleton of differentiated smooth muscle cells appears to function midway between that of less dynamic striated muscle cells and that of very plastic proliferative cells such as fibroblasts. Michael and Kate Bárány keenly followed and participated in some of these studies, consistent with their broad interest in actin function and smooth muscle mechanisms. As a way of honoring the memory of these two pioneer members of the muscle research community, we review data on distribution and remodeling of thin filaments in smooth muscle cells, one of the many research topics that intrigued them.
Links	PubMed PMC3394904 Online version:10.1007/s10974-012-9283-z
Keywords	Actins/chemistry; Actins/metabolism; Animals; Cytoskeleton/chemistry; Cytoskeleton/metabolism; Humans; Models, Molecular; Molecular Structure; Muscle Contraction; Muscle, Smooth/chemistry; Muscle, Smooth/metabolism
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