GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:22295022
| Citation |
Hou, Z, Zhou, Y, Wang, H, Bai, H, Meng, J, Xue, X and Luo, X (2011) Co-blockade of mecR1/blaR1 signal pathway to restore antibiotic susceptibility in clinical isolates of methicillin-resistant Staphylococcus aureus. Arch Med Sci 7:414-22 |
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| Abstract |
Methicillin-resistant Staphylococcus aureus (MRSA) is caused by the production of low-affinity penicillin-binding protein 2a and β-lactamases, which are encoded by mecA and blaZ, respectively. Expressions of the two key genes are mutually regulated by MecI and BlaI. The aim of this study was to design specific anti-mecR1 and anti-blaR1 deoxyribozymes and identify the restoration of susceptibility in MRSA isolates with mecI or blaI or no deletions by interfering with the mutual regulation of mecA and blaZ. |
| Links |
PubMed PMC3258742 Online version:10.5114/aoms.2011.23404 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016481: negative regulation of transcription |
ECO:0000314: |
1 |
Figure 1, part A1 |
complete | ||||
See also
References
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