GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:22267675
| Citation |
Zou, L, Zeng, Q, Lin, H, Gyaneshwar, P, Chen, G and Yang, CH (2012) SlyA regulates type III secretion system (T3SS) genes in parallel with the T3SS master regulator HrpL in Dickeya dadantii 3937. Appl. Environ. Microbiol. 78:2888-95 |
|---|---|
| Abstract |
The hypersensitive response and pathogenicity (hrp) genes of Dickeya dadantii 3937 encode a type III secretion system (T3SS) which is essential for its full virulence. Previous studies of the T3SS regulation in D. dadantii 3937 revealed that the expression of the hrp genes is regulated by a master regulator, HrpL, through the HrpX-HrpY-HrpS-HrpL and GacS-GacA-rsmB-RsmA pathways. In this work, we identified a novel regulator of the SlyA/MarR family, SlyA, which regulates hrp genes of the HrpL regulon in parallel with HrpL in D. dadantii. SlyA regulates the T3SS in a two-tier manner. It negatively regulates the expression of hrpL by downregulating hrpS and upregulating rsmA. Interestingly, concomitant with its downregulation of the hrpL, SlyA positively regulates the expression of hrpA and hrpN, two hrp genes located in the HrpL regulon. In contrast to Pectobacterium carotovorum, the expression of slyA is not controlled by ExpR and ExpI in D. dadantii 3937. We further show that SlyA is involved in controlling swimming motility and pellicle formation in D. dadantii 3937. |
| Links |
PubMed PMC3318817 Online version:10.1128/AEM.07021-11 |
| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacterial Secretion Systems; Enterobacteriaceae/genetics; Enterobacteriaceae/metabolism; Enterobacteriaceae/physiology; Gene Expression Regulation, Bacterial; Locomotion; Protein Transport; Regulon; Virulence Factors/genetics; Virulence Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: |
P |
Figure 2A shows that in a slyA mutant, hrp genes controlling the Type 3 Secretion System are overexpressed. |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
