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PMID:22231115
| Citation |
Knappskog, S and Lønning, PE Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk. Transcription 2:207-10 |
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| Abstract |
The proto-oncogene MDM2 inhibits p53 and plays a key role in cell growth control and apoptosis. Identification of two antagonizing MDM2 polymorphisms, SNP285 and SNP309, affecting cancer risk through modulation of Sp1 transcription factor binding, shed new light on the biological activity and phylogeny of this gene. |
| Links |
PubMed PMC3265776 Online version:10.4161/trns.2.5.16813 |
| Keywords |
Humans; Neoplasms/etiology; Neoplasms/genetics; Neoplasms/pathology; Polymorphism, Single Nucleotide; Protein Binding/genetics; Proto-Oncogene Proteins c-mdm2/genetics; Proto-Oncogene Proteins c-mdm2/metabolism; Risk Factors; Sp1 Transcription Factor/genetics; Sp1 Transcription Factor/metabolism; Transcription, Genetic; Tumor Suppressor Protein p53/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
References
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