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PMID:22099983
| Citation |
Kim, JI, Chakraborty, P, Wang, Z and Daaka, Y (2012) G-protein coupled receptor kinase 5 regulates prostate tumor growth. J. Urol. 187:322-9 |
|---|---|
| Abstract |
The limited success of cancer therapeutics is largely attributable to the ability of cancer to become resistant to conventional cytotoxic chemotherapy. Thus, further identification of signaling molecules and pathways that influence tumorigenesis is needed to increase the overall therapeutic options. GRKs, originally recognized for their conserved role in GPCR signal control, have now emerged as regulators of additional biological molecules and functions. |
| Links |
PubMed Online version:10.1016/j.juro.2011.09.049 |
| Keywords |
Animals; Cell Line, Tumor; Cell Proliferation; Disease Progression; G-Protein-Coupled Receptor Kinase 5/physiology; Humans; Male; Mice; Prostatic Neoplasms/pathology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008284: positive regulation of cell proliferation |
ECO:0000315: |
P |
Figure 1 |
complete | ||||
| GO:0051726: regulation of cell cycle |
ECO:0000315: |
P |
Figure 3. |
complete | ||||
|
involved_in |
GO:0008284: positive regulation of cell population proliferation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051726: regulation of cell cycle |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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