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PMID:22092815
| Citation |
Michaux, C, Martini, C, Hanin, A, Auffray, Y, Hartke, A and Giard, JC (2011) SlyA regulator is involved in bile salts stress response of Enterococcus faecalis. FEMS Microbiol. Lett. 324:142-6 |
|---|---|
| Abstract |
SlyA is a newly transcriptional regulator identified in Enterococcus faecalis that is involved in the virulence, persistence in mouse kidneys and liver, and survival inside peritoneal macrophages. In this study we searched for environmental conditions that affect expression of the corresponding gene. Of the several stress conditions tested, only bile salts (0.08%) significantly induced transcription of slyA. In addition, the growth of ΔslyA mutant strain was significantly impaired in the presence of bile salts. To increase knowledge of SlyA regulon, real-time quantitative PCR was performed and revealed that expression of EF_3005, which encodes a choloylglycine hydrolase, is negatively regulated by SlyA. |
| Links |
PubMed Online version:10.1111/j.1574-6968.2011.02390.x |
| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bile Acids and Salts/metabolism; Enterococcus faecalis/genetics; Enterococcus faecalis/growth & development; Enterococcus faecalis/physiology; Gastrointestinal Tract/metabolism; Gastrointestinal Tract/microbiology; Gene Expression Regulation, Bacterial; Genes, Regulator; Humans; Models, Biological; Regulon; Stress, Physiological; Transcription Factors/genetics; Transcription Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0033554: cellular response to stress |
ECO:0000315: |
P |
Figure 2 indicates that a slyA mutant strain is significantly impaired in its ability to grow under bile salt stress (in the presence of 0.08% bile salts), compared to wild-type E. faecalis |
complete | ||||
| GO:0033554: cellular response to stress |
ECO:0000314: |
P |
Figure 1 shows induction of slyA under bile salt stress conditions. |
complete | ||||
See also
References
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