GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:22090137
| Citation |
Xu, P, Luthra, P, Li, Z, Fuentes, S, D'Andrea, JA, Wu, J, Rubin, S, Rota, PA and He, B (2012) The V protein of mumps virus plays a critical role in pathogenesis. J. Virol. 86:1768-76 |
|---|---|
| Abstract |
Mumps virus (MuV) causes an acute infection in humans characterized by a wide array of symptoms ranging from relatively mild manifestations, such as parotitis, to more-severe complications, such as meningitis and encephalitis. Widespread mumps vaccination has reduced mumps incidence dramatically; however, outbreaks still occur in vaccinated populations. The V protein of MuV, when expressed in cell culture, blocks interferon (IFN) expression and signaling and interleukin-6 (IL-6) signaling. In this work, we generated a recombinant MuV incapable of expressing the V protein (rMuVΔV). The rescued MuV was derived from a clinical wild-type isolate from a recent outbreak in the United States (MuV(Iowa/US/06), G genotype). Analysis of the virus confirmed the roles of V protein in blocking IFN expression and signaling and IL-6 signaling. We also found that the rMuV(Iowa/US/06)ΔV virus induced high levels of IL-6 expression in vitro, suggesting that V plays a role in reducing IL-6 expression. In vivo, the rMuV(Iowa/US/06)ΔV virus was highly attenuated, indicating that the V protein plays an essential role in viral virulence. |
| Links |
PubMed PMC3264346 Online version:10.1128/JVI.06019-11 |
| Keywords |
Animals; Cell Line; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; In Situ Nick-End Labeling; Mumps virus/metabolism; Mumps virus/pathogenicity; Viral Proteins/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0039565: suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process |
ECO:0000315: |
P |
Fig 7 |
complete | ||||
|
involved_in |
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
