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PMID:21986708
| Citation |
Filippin-Monteiro, FB, de Oliveira, EM, Sandri, S, Knebel, FH, Albuquerque, RC and Campa, A (2012) Serum amyloid A is a growth factor for 3T3-L1 adipocytes, inhibits differentiation and promotes insulin resistance. Int J Obes (Lond) 36:1032-9 |
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| Abstract |
Serum amyloid A (SAA) is an acute-phase protein that has been recently correlated with obesity and insulin resistance. Therefore, we first examined whether human recombinant SAA (rSAA) could affect the proliferation, differentiation and metabolism of 3T3-L1 preadipocytes. |
| Links |
PubMed PMC3419975 Online version:10.1038/ijo.2011.193 |
| Keywords |
3T3-L1 Cells/metabolism; Adipocytes/metabolism; Animals; Cell Differentiation/genetics; Cell Proliferation; Deoxyglucose/metabolism; Flow Cytometry; Humans; Insulin Resistance/genetics; Intercellular Signaling Peptides and Proteins; Mice; Mice, Obese; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Serum Amyloid A Protein/genetics; Serum Amyloid A Protein/metabolism; Up-Regulation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0070346: fat cell proliferation |
ECO:0000314: |
P |
Fig. 2C Both Insulin and rSAA treated cells show increased rate of proliferation compared to insulin treated cells. |
complete | ||||
See also
References
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