PMID:21892957

Citation	Dreyfus, DH, Liu, Y, Ghoda, LY and Chang, JT (2011) Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53. Virol. J. 8:422
Abstract	The carboxyl terminal of Epstein-Barr virus (EBV) ZEBRA protein (also termed BZLF-1 encoded replication protein Zta or ZEBRA) binds to both NF-κB and p53. The authors have previously suggested that this interaction results from an ankyrin-like region of the ZEBRA protein since ankyrin proteins such as IκB interact with NF-κB and p53 proteins. These interactions may play a role in immunopathology and viral carcinogenesis in B lymphocytes as well as other cell types transiently infected by EBV such as T lymphocytes, macrophages and epithelial cells.
Links	PubMed PMC3180424 Online version:10.1186/1743-422X-8-422
Keywords	Amino Acid Sequence; Ankyrins/chemistry; Ankyrins/genetics; Ankyrins/metabolism; Binding Sites/genetics; Epstein-Barr Virus Infections/complications; Epstein-Barr Virus Infections/diagnosis; Epstein-Barr Virus Infections/epidemiology; Epstein-Barr Virus Infections/virology; Herpesvirus 4, Human/genetics; Herpesvirus 4, Human/immunology; Humans; Models, Molecular; Molecular Sequence Data; NF-kappa B/genetics; NF-kappa B/metabolism; Phylogeny; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary/genetics; Sequence Alignment; Trans-Activators/chemistry; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription, Genetic; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism
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Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status

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