PMID:21824506

Citation	Shen, D, Zhang, Q, Gao, X, Gu, X and Ding, F (2011) Age-related changes in myelin morphology, electrophysiological property and myelin-associated protein expression of mouse sciatic nerves. Neurosci. Lett. 502:162-7
Abstract	This study investigated the morphological and functional changes in peripheral nerves during the maturation and aging process. In a mouse sciatic nerve model, electron micrographs revealed that the number of myelin sheath lamellae gradually increased from 1 week through 12 months of age, when it reached the peak value, and then remained unchanged until 18 months of age; electrophysiological examinations showed that the amplitude of compound muscle action potentials gradually increased from 1 week through 18 months of age and displayed a positive linear correlation with the number of myelin sheath lamellae. Western blot analysis exhibited the age-related expression patterns of four myelin-associated proteins, i.e., myelin-associated glycoprotein (MAG), myelin basic protein (MBP), glycoprotein P0 (P0) and peripheral myelin protein 22 (PMP22). And MAG, MBP and PMP22 showed linear negative or positive correlations with the number of myelin sheath lamellae. Our results suggest that the morphological and functional changes in peripheral nerves are closely related to each other and the myelin-associated proteins perform distinct actions on the formation, maturation, degeneration and regeneration of myelin sheaths.
Links	PubMed Online version:10.1016/j.neulet.2011.07.034
Keywords	Animals; Animals, Newborn; Cell Differentiation/genetics; Cell Differentiation/physiology; Electrophysiology; Female; Gene Expression Regulation, Developmental/physiology; Male; Mice; Mice, Inbred ICR; Myelin Proteins/biosynthesis; Myelin Proteins/genetics; Myelin Proteins/physiology; Myelin Sheath/physiology; Nerve Degeneration/metabolism; Nerve Degeneration/pathology; Nerve Degeneration/physiopathology; Nerve Fibers, Myelinated/metabolism; Nerve Fibers, Myelinated/physiology; Nerve Regeneration/genetics; Nerve Regeneration/physiology; Sciatic Nerve/cytology; Sciatic Nerve/growth & development; Sciatic Nerve/physiology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:SMAGP		GO:0007422: peripheral nervous system development	ECO:0000315:		P		Figure 3 The protein expressions of MAG, MBP, P0 and PMP22 in mouse sciatic nerves	complete CACAO 9659

References

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