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PMID:21799871
| Citation |
Kurokawa, H, Kato, K, Iwanaga, T, Sugi, T, Sudo, A, Kobayashi, K, Gong, H, Takemae, H, Recuenco, FC, Horimoto, T and Akashi, H (2011) Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. PLoS ONE 6:e22492 |
|---|---|
| Abstract |
cAMP-dependent protein kinase (PKA) has been implicated in the asexual stage of the Toxoplasma gondii life cycle through assaying the effect of a PKA-specific inhibitor on its growth rate. Since inhibition of the host cell PKA cannot be ruled out, a more precise evaluation of the role of PKA, as well as characterization of the kinase itself, is necessary. |
| Links |
PubMed PMC3140512 Online version:10.1371/journal.pone.0022492 |
| Keywords |
Adenosine Triphosphate/metabolism; Amino Acid Sequence; Binding, Competitive; Catalytic Domain; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases/chemistry; Cyclic AMP-Dependent Protein Kinases/genetics; Cyclic AMP-Dependent Protein Kinases/metabolism; Gene Expression Regulation, Enzymologic; Isoquinolines/pharmacology; Molecular Sequence Data; Peptides/pharmacology; Protein Kinase Inhibitors/pharmacology; Sulfonamides/pharmacology; Toxoplasma/enzymology; Toxoplasma/growth & development |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0004672: protein kinase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046777: protein autophosphorylation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0004672: protein kinase activity |
ECO:0000314: |
F |
From table 3, it shows that the protein is capable of phosphorylation. |
complete | ||||
| GO:0046777: protein autophosphorylation |
ECO:0000314: |
P |
From Fig. 3, we are shown that this protein: TgPKA-C autophosphorylates. |
complete | ||||
| GO:0006468: protein phosphorylation |
ECO:0000314: |
P |
From fig. 3 part D, we can see that TgPKA-C has the ability to phosphorylate proteins. (in this case, histone IIAS) |
complete | ||||
|
involved_in |
GO:0006468: protein phosphorylation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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