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PMID:21791059
| Citation |
Palma, L, Sfara, C, Antonelli, A and Magnani, M (2011) Dexamethasone restrains ongoing expression of interleukin-23p19 in peripheral blood-derived human macrophages. BMC Pharmacol. 11:8 |
|---|---|
| Abstract |
Since its recent discovery, interleukin-23 has been shown to be involved in the pathogenesis of autoimmune diseases favoring the development of a T cell subset referred to as T helper 17. Glucocorticoids are widely employed in inflammatory and autoimmune diseases as they inhibit pro-inflammatory signaling and prevent production of inflammation mediators. Very limited information is available about the efficacy of synthetic glucocorticoids in containing the expression of interleukin-23 under cell activation. |
| Links |
PubMed PMC3166892 Online version:10.1186/1471-2210-11-8 |
| Keywords |
Adult; Blotting, Western; Cell Line, Tumor; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cells, Cultured; Cytosol/drug effects; Cytosol/metabolism; Dexamethasone/pharmacology; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1/metabolism; Enzyme-Linked Immunosorbent Assay; Gene Expression/drug effects; Glucocorticoids/pharmacology; Humans; Interleukin-23 Subunit p19/genetics; Interleukin-23 Subunit p19/metabolism; Lipopolysaccharides/pharmacology; Macrophages/cytology; Macrophages/drug effects; Macrophages/metabolism; Monocytes/cytology; Monocytes/drug effects; Monocytes/metabolism; Phosphorylation/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcription Factor RelA/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism |
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Significance
Annotations
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