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PMID:21593014
| Citation |
Kashyap, L, Perera, S and Fisher, AL (2012) Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 67:56-65 |
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| Abstract |
Aging in humans is characterized by a progressive loss of muscle mass and strength known as sarcopenia. Although considered to be a normal aspect of aging, the loss of strength can have significant effects on the health, functioning, and independence of elderly individuals. Although these aspects of sarcopenia have been well studied, the molecular mechanisms leading to its development are still unclear. The nematode Caenorhabditis elegans might be a novel animal model for sarcopenia as worms experience sarcopenia during aging and mutations affecting the daf-2/insulin-like signaling pathway are able to delay this process. |
| Links |
PubMed PMC3260486 Online version:10.1093/gerona/glr072 |
| Keywords |
Aging/genetics; Aging/metabolism; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Disease Models, Animal; Humans; Longevity/genetics; RNA Interference; Receptor, Insulin/genetics; Receptor, Insulin/metabolism; Sarcopenia/genetics; Sarcopenia/metabolism; Sequence Homology, Amino Acid; Transcription Factors/genetics; Transcription Factors/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
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