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PMID:21481199
| Citation |
Kvachadze, L, Balarjishvili, N, Meskhi, T, Tevdoradze, E, Skhirtladze, N, Pataridze, T, Adamia, R, Topuria, T, Kutter, E, Rohde, C and Kutateladze, M (2011) Evaluation of lytic activity of staphylococcal bacteriophage Sb-1 against freshly isolated clinical pathogens. Microb Biotechnol 4:643-50 |
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| Abstract |
In recent decades the increase in antibiotic-resistant bacterial strains has become a serious threat to the treatment of infectious diseases. Drug resistance of Staphylococcus aureus has become a major problem in hospitals of many countries, including developed ones. Today the interest in alternative remedies to antibiotics, including bacteriophage treatment, is gaining new ground. Here, we describe the staphylococcal bacteriophage Sb-1 - a key component of therapeutic phage preparation that was successfully used against staphylococcal infections during many years in the Former Soviet Union. This phage still reveals a high spectrum of lytic activity in vitro against freshly isolated, genetically different clinical samples (including methicillin-resistant S. aureus) obtained from the local hospitals, as well as the clinics from different geographical areas. The sequence analyses of phage genome showed absence of bacterial virulence genes. A case report describes a promising clinical response after phage application in patient with cystic fibrosis and indicates the efficacy of usage of Sb-1 phage against various staphylococcal infections. |
| Links |
PubMed PMC3819013 Online version:10.1111/j.1751-7915.2011.00259.x |
| Keywords |
Anti-Bacterial Agents/pharmacology; Base Sequence; Biological Therapy/methods; Child; Drug Resistance, Bacterial; Female; Genome, Viral; Humans; Molecular Sequence Data; Phylogeny; Staphylococcal Infections/microbiology; Staphylococcal Infections/therapy; Staphylococcus Phages/genetics; Staphylococcus Phages/physiology; Staphylococcus aureus/classification; Staphylococcus aureus/genetics; Staphylococcus aureus/isolation & purification; Staphylococcus aureus/virology; Viral Proteins/genetics; Viral Proteins/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0098025: virus tail, baseplate |
ECO:0000247: |
UniProtKB:A8AST7
|
C |
Figure 3 shows gp103 is products putative baseplate in Listeria Bacteriophage A511 and comparison of the structural proteins with Sb-1 shows Sb-1 has similar DNA band. |
complete | |||
Notes
See also
References
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