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PMID:21463460
| Citation |
Yang, CC, Chen, D, Lee, SS and Walter, L (2011) The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell 10:724-8 |
|---|---|
| Abstract |
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging. |
| Links |
PubMed PMC3135752 Online version:10.1111/j.1474-9726.2011.00711.x |
| Keywords |
Animals; Animals, Genetically Modified; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Dynamins/genetics; Dynamins/metabolism; Insulin/metabolism; Longevity/physiology; Phenotype; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
References
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