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PMID:21373849

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Citation

Oguro, M, Koike, M, Ueno, T, Asaoka, D, Mori, H, Nagahara, A, Uchiyama, Y and Watanabe, S (2011) Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease. J. Gastroenterol. 46:629-38

Abstract

The aim of this study was to characterize pathological lesions of the esophageal epithelial tight junction (TJ) complex in a rat reflux esophagitis (RE) model in a search for a reliable diagnostic indicator.

Links

PubMed Online version:10.1007/s00535-011-0390-1

Keywords

2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage; 2-Pyridinylmethylsulfinylbenzimidazoles/pharmacology; Animals; Claudin-1; Claudin-3; Claudin-4; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells/metabolism; Esophagitis, Peptic/diagnosis; Esophagitis, Peptic/drug therapy; Esophagitis, Peptic/pathology; Inflammation/diagnosis; Inflammation/drug therapy; Inflammation/pathology; Male; Membrane Proteins/metabolism; Microscopy, Confocal; Microscopy, Fluorescence; Proton Pump Inhibitors/administration & dosage; Proton Pump Inhibitors/pharmacology; Rabeprazole; Rats; Rats, Wistar; Tight Junctions/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:CLD3

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

See also

References

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