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PMID:21333538
Citation |
Nimchuk, ZL, Tarr, PT, Ohno, C, Qu, X and Meyerowitz, EM (2011) Plant stem cell signaling involves ligand-dependent trafficking of the CLAVATA1 receptor kinase. Curr. Biol. 21:345-52 |
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Abstract |
Cell numbers in above-ground meristems of plants are thought to be maintained by a feedback loop driven by perception of the glycopeptide ligand CLAVATA3 (CLV3) by the CLAVATA1 (CLV1) receptor kinase and the CLV2/CORYNE (CRN) receptor-like complex. CLV3 produced in the stem cells at the meristem apex limits the expression level of the stem cell-promoting homeodomain protein WUSCHEL (WUS) in the cells beneath, where CLV1 and WUS RNA are localized. WUS downregulation nonautonomously reduces stem cell proliferation. Overexpression of CLV3 eliminates the stem cells, causing meristem termination, and loss of CLV3 function allows meristem overproliferation. There are many questions regarding the CLV3/CLV1 interaction, including where in the meristem it occurs, how it is regulated, and how it is that a large range of CLV3 concentrations gives no meristem size phenotype. |
Links |
PubMed PMC3072602 Online version:10.1016/j.cub.2011.01.039 |
Keywords |
Arabidopsis/metabolism; Arabidopsis/physiology; Arabidopsis Proteins/metabolism; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Plant/physiology; Genetic Vectors/genetics; Homeodomain Proteins/metabolism; Meristem/metabolism; Meristem/physiology; Microscopy, Confocal; Protein Transport/physiology; Receptor Protein-Tyrosine Kinases/metabolism; Signal Transduction/physiology |
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Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0000325: plant-type vacuole |
ECO:0000314: |
C |
Figure 1. |
complete | ||||
part_of |
GO:0000325: plant-type vacuole |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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