GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:21333538

From GONUTS
Jump to: navigation, search
Citation

Nimchuk, ZL, Tarr, PT, Ohno, C, Qu, X and Meyerowitz, EM (2011) Plant stem cell signaling involves ligand-dependent trafficking of the CLAVATA1 receptor kinase. Curr. Biol. 21:345-52

Abstract

Cell numbers in above-ground meristems of plants are thought to be maintained by a feedback loop driven by perception of the glycopeptide ligand CLAVATA3 (CLV3) by the CLAVATA1 (CLV1) receptor kinase and the CLV2/CORYNE (CRN) receptor-like complex. CLV3 produced in the stem cells at the meristem apex limits the expression level of the stem cell-promoting homeodomain protein WUSCHEL (WUS) in the cells beneath, where CLV1 and WUS RNA are localized. WUS downregulation nonautonomously reduces stem cell proliferation. Overexpression of CLV3 eliminates the stem cells, causing meristem termination, and loss of CLV3 function allows meristem overproliferation. There are many questions regarding the CLV3/CLV1 interaction, including where in the meristem it occurs, how it is regulated, and how it is that a large range of CLV3 concentrations gives no meristem size phenotype.

Links

PubMed PMC3072602 Online version:10.1016/j.cub.2011.01.039

Keywords

Arabidopsis/metabolism; Arabidopsis/physiology; Arabidopsis Proteins/metabolism; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Plant/physiology; Genetic Vectors/genetics; Homeodomain Proteins/metabolism; Meristem/metabolism; Meristem/physiology; Microscopy, Confocal; Protein Transport/physiology; Receptor Protein-Tyrosine Kinases/metabolism; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:CLV1

GO:0000325: plant-type vacuole

ECO:0000314:

C

Figure 1.

complete
CACAO 8388

ARATH:CLV1

part_of

GO:0000325: plant-type vacuole

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.