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PMID:21252314
| Citation |
Lebreton, A, Lakisic, G, Job, V, Fritsch, L, Tham, TN, Camejo, A, Matteï, PJ, Regnault, B, Nahori, MA, Cabanes, D, Gautreau, A, Ait-Si-Ali, S, Dessen, A, Cossart, P and Bierne, H (2011) A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science 331:1319-21 |
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| Abstract |
Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host. |
| Links |
PubMed Online version:10.1126/science.1200120 |
| Keywords |
Amino Acid Sequence; Animals; Cell Line; Cell Line, Tumor; Cell Nucleus/metabolism; Chromatin/metabolism; Chromosomal Proteins, Non-Histone/metabolism; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Interferons/genetics; Interferons/immunology; Interferons/metabolism; Interleukins/genetics; Interleukins/immunology; Interleukins/metabolism; Listeria monocytogenes/genetics; Listeria monocytogenes/metabolism; Listeria monocytogenes/pathogenicity; Listeriosis/immunology; Listeriosis/microbiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Signal Transduction; Virulence Factors/chemistry; Virulence Factors/genetics; Virulence Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005576: extracellular region |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0005576: extracellular region |
ECO:0000314: |
C |
Figure 1. The secreted virulence factor LntA targets the nuclear protein BAHD1.lntA is regulated by PrfA and sB. |
complete | ||||
See also
References
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