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PMID:21108829
| Citation |
Leadsham, JE and Gourlay, CW (2010) cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation. BMC Cell Biol. 11:92 |
|---|---|
| Abstract |
Appropriate control of mitochondrial function, morphology and biogenesis are crucial determinants of the general health of eukaryotic cells. It is therefore imperative that we understand the mechanisms that co-ordinate mitochondrial function with environmental signaling systems. The regulation of yeast mitochondrial function in response to nutritional change can be modulated by PKA activity. Unregulated PKA activity can lead to the production of mitochondria that are prone to the production of ROS, and an apoptotic form of cell death. |
| Links |
PubMed PMC3001716 Online version:10.1186/1471-2121-11-92 |
| Keywords |
Apoptosis; CCAAT-Binding Factor/metabolism; Catalytic Domain; Cyclic AMP/metabolism; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/metabolism; Cyclic AMP-Dependent Protein Kinases/metabolism; Gene Expression Regulation, Fungal; Membrane Proteins/metabolism; Mitochondria/metabolism; Mitochondrial Proteins/metabolism; Reactive Oxygen Species/metabolism; Repressor Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Signal Transduction; Transcription Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005746: mitochondrial respirasome |
ECO:0000315: mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0005746: mitochondrial respiratory chain |
ECO:0000315: |
C |
fig. 7 |
complete | ||||
See also
References
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