PMID:21091498

Citation	Dubarry, N, Possoz, C and Barre, FX (2010) Multiple regions along the Escherichia coli FtsK protein are implicated in cell division. Mol. Microbiol. 78:1088-100
Abstract	Escherichia coli FtsK is a large 1329 aa integral membrane protein, which links cell division and chromosome segregation through the respective activities of its 200 aa amino-terminal domain, FtsK(N), and its 500 aa carboxy-terminal domain, FtsK(C). A long 600 aa linker, FtsK(L), connects these two domains. Only FtsK(N) is essential for cell division. However, previous observations suggested that the cytoplasmic part of FtsK also participates in the process of septation. Here, we identify two distinct regions within FtsK(L), FtsK(179-331) and FtsK(332-641), which together with FtsK(N), are required for normal septation. We discuss how the implication of multiple regions along the FtsK protein in cell division could participate in the co-ordination of this process with the last stages of chromosome segregation.
Links	PubMed Online version:10.1111/j.1365-2958.2010.07412.x
Keywords	Amino Acid Motifs; Cell Division; Escherichia coli/chemistry; Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
ECOLI:FTSK		GO:0051301: cell division	ECO:0000315:		P		As shown in figure 5, cells with a deletion mutation of varying parts of FtsK form elongate rods, which is indicative of the cell's inability to divide.	complete CACAO 6611
ECOLI:FTSK	involved_in	GO:0051301: cell division	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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