GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:20832057
| Citation |
Drerup, JM, Hayashi, K, Cui, H, Mettlach, GL, Long, MA, Marvin, M, Sun, X, Goldberg, MS, Lutter, M and Bibb, JA (2010) Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35. Biol. Psychiatry 68:1163-71 |
|---|---|
| Abstract |
Attention-deficit/hyperactivity disorder (ADHD) may result from delayed establishment of corticolimbic circuitry or perturbed dopamine (DA) neurotransmission. Despite the widespread use of stimulants to treat ADHD, little is known regarding their long-term effects on neurotransmitter levels and metabolism. Cyclin-dependent kinase 5 (Cdk5) regulates DA signaling through control of synthesis, postsynaptic responses, and vesicle release. Mice lacking the Cdk5-activating cofactor p35 are deficient in cortical lamination, suggesting altered motor/reward circuitry. |
| Links |
PubMed PMC2997929 Online version:10.1016/j.biopsych.2010.07.016 |
| Keywords |
Animals; Atrophy/genetics; Attention Deficit Disorder with Hyperactivity/genetics; Attention Deficit Disorder with Hyperactivity/metabolism; Attention Deficit Disorder with Hyperactivity/pathology; Brain/metabolism; Brain/pathology; Disease Models, Animal; Dopamine/metabolism; Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism; Fluorodeoxyglucose F18/metabolism; Male; Methylphenidate/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity/drug effects; Motor Activity/genetics; Neural Pathways/pathology; Phenotype; Phosphotransferases/genetics; Positron-Emission Tomography/methods; Prefrontal Cortex/drug effects; Prefrontal Cortex/metabolism; Receptors, AMPA/metabolism; Serotonin/metabolism; Synaptic Transmission/drug effects; Synaptic Transmission/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0046325: negative regulation of glucose import |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0046325: negative regulation of glucose import |
ECO:0000315: |
P |
Figure 1 shows that P35 knockout results in increased rate of cortical glucose uptake. |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
