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PMID:20550930
| Citation |
Gerdes, K, Howard, M and Szardenings, F (2010) Pushing and pulling in prokaryotic DNA segregation. Cell 141:927-42 |
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| Abstract |
In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics. |
| Links |
PubMed Online version:10.1016/j.cell.2010.05.033 |
| Keywords |
Actins/metabolism; Bacteria/cytology; Bacteria/metabolism; Bacterial Proteins/metabolism; Chromosomes, Bacterial/metabolism; DNA, Bacterial/metabolism; Plasmids/metabolism; Tubulin/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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Notes
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References
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