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PMID:20538988
| Citation |
Contín, MA, Verra, DM, Salvador, G, Ilincheta, M, Giusto, NM and Guido, ME (2010) Light activation of the phosphoinositide cycle in intrinsically photosensitive chicken retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 51:5491-8 |
|---|---|
| Abstract |
In vertebrates, intrinsically photosensitive retinal ganglion cells (ipRGCs) acting as nonvisual photoreceptors transmit environmental illumination information to the brain, regulating diverse non-image-forming tasks. The phototransduction cascade in chicken ipRGCs has been shown to resemble that of rhabdomeric photoreceptors and involves phospholipase C (PLC) activation. The current work was an investigation of the participation of the phosphoinositide (PIP) cycle in this mechanism and of whether changes in activities of inositol 1,4,5-trisphosphate (IP(3)) and PIP kinase are triggered by light. |
| Links |
PubMed Online version:10.1167/iovs.10-5643 |
| Keywords |
1-Phosphatidylinositol 4-Kinase/metabolism; Aniline Compounds/metabolism; Animals; Calcium/metabolism; Cells, Cultured; Chick Embryo; DNA Primers; Dark Adaptation; Diacylglycerol Kinase/metabolism; Estrenes/pharmacology; Inositol 1,4,5-Trisphosphate/metabolism; Light; Microscopy, Fluorescence; Phosphatidylinositols/metabolism; Phosphodiesterase Inhibitors/pharmacology; Photic Stimulation; Pyrrolidinones/pharmacology; RNA, Messenger/genetics; Retinal Ganglion Cells/metabolism; Retinal Ganglion Cells/radiation effects; Reverse Transcriptase Polymerase Chain Reaction; Rod Opsins/genetics; Type C Phospholipases/antagonists & inhibitors; Xanthenes/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005623: cell |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(CL:0000740) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005623: cell |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(CL:0000740) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005623: cell |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(CL:0000740) |
Seeded From UniProt |
complete | ||
Notes
See also
References
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