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PMID:20123895
| Citation |
Wang, JK, Tsai, MC, Poulin, G, Adler, AS, Chen, S, Liu, H, Shi, Y and Chang, HY (2010) The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev. 24:327-32 |
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| Abstract |
Trimethylation of histone H3 on Lys 27 (H3K27me3) is key for cell fate regulation. The H3K27me3 demethylase UTX functions in development and tumor suppression with undefined mechanisms. Here, genome-wide chromatin occupancy analysis of UTX and associated histone modifications reveals distinct classes of UTX target genes, including genes encoding Retinoblastoma (RB)-binding proteins. UTX removes H3K27me3 and maintains expression of several RB-binding proteins, enabling cell cycle arrest. Genetic interactions in mammalian cells and Caenorhabditis elegans show that UTX regulates cell fates via RB-dependent pathways. Thus, UTX defines an evolutionarily conserved mechanism to enable coordinate transcription of a RB network in cell fate control. |
| Links |
PubMed PMC2816731 Online version:10.1101/gad.1882610 |
| Keywords |
Animals; Caenorhabditis elegans/metabolism; Cell Differentiation/physiology; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chromatin/metabolism; Gene Expression Regulation; Genome/genetics; Humans; Jumonji Domain-Containing Histone Demethylases/genetics; Jumonji Domain-Containing Histone Demethylases/metabolism; Methylation; Mice; Neoplasms/metabolism; Retinoblastoma Binding Proteins/genetics; Retinoblastoma Binding Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
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