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PMID:20111601

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Citation

Gonzalez-Cabo, P, Ros, S and Palau, F (2010) Flavin adenine dinucleotide rescues the phenotype of frataxin deficiency. PLoS ONE 5:e8872

Abstract

Friedreich ataxia is a neurodegenerative disease caused by the lack of frataxin, a mitochondrial protein. We previously demonstrated that frataxin interacts with complex II subunits of the electronic transport chain (ETC) and putative electronic transfer flavoproteins, suggesting that frataxin could participate in the oxidative phosphorylation.

Links

PubMed PMC2810331 Online version:10.1371/journal.pone.0008872

Keywords

Adenosine Triphosphate/biosynthesis; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Dose-Response Relationship, Drug; Flavin-Adenine Dinucleotide/pharmacology; Gene Knockdown Techniques; Iron-Binding Proteins/genetics; Models, Biological; Oxidative Phosphorylation; Phenotype; Recombination, Genetic; Saccharomyces cerevisiae/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status


See also

References

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