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PMID:20003541
| Citation |
Shimuta, K, Ohnishi, M, Iyoda, S, Gotoh, N, Koizumi, N and Watanabe, H (2009) The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA. BMC Microbiol. 9:261 |
|---|---|
| Abstract |
Serratia marcescens is a gram-negative bacterium and often causes nosocomial infections. There have been few studies of the virulence factors of this bacterium. The only S. marcescens hemolytic and cytotoxic factor reported, thus far, is the hemolysin ShlA. |
| Links |
PubMed PMC2800117 Online version:10.1186/1471-2180-9-261 |
| Keywords |
Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cloning, Molecular; DNA, Bacterial/genetics; Erythrocytes/microbiology; HeLa Cells; Hemolysin Proteins/genetics; Hemolysin Proteins/metabolism; Hemolysis; Horses; Humans; Lysophospholipids/biosynthesis; Phospholipases A/genetics; Phospholipases A/metabolism; Sequence Analysis, DNA; Sequence Deletion; Serratia marcescens/enzymology; Serratia marcescens/genetics; Sheep |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0019836: hemolysis by symbiont of host erythrocytes |
ECO:0000315: |
P |
ShlAB was responsible for direct contact hemolysis. PhlAB was responsible for extracellular hemolysis without contact. Figure 2 shows how mutants lacking PhlAB lost their hemolytic ability without contact. When these cells were given PhlAB, they regained their hemolytic activity without needing contact. |
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See also
References
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