PMID:19921263

Citation	Armstrong, KR and Chamberlin, HM (2010) Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Mol. Genet. Genomics 283:73-87
Abstract	Excretory renal organs are critical in animals for osmoregulation and the elimination of waste. Renal organs across a range of species exhibit cellular and molecular similarities. For example, class III POU-homeodomain transcription factors are expressed in the renal organs of many invertebrates and vertebrates. However, the functional role for these factors is not well characterized. To better understand the role of class III POU-homeodomain proteins in animal excretory systems, we have characterized a set of genes expressed in the Caenorhabditis elegans excretory cell, and determined their regulation by the POU-III transcription factor CEH-6. Our molecular and biochemical studies show that CEH-6 regulates a subset of genes expressed in the excretory cell. Additionally, we find that the CEH-6-dependent genes share two molecular features: they contain at least one octamer regulatory element and they encode for transport and channel proteins. This work suggests that a role for POU-III factors in renal organs is to coordinate the expression of a set of functionally related genes.
Links	PubMed Online version:10.1007/s00438-009-0497-8
Keywords	Animals; Base Sequence; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Gene Expression Regulation; Gene Regulatory Networks; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Organic Anion Transporters/genetics; POU Domain Factors/genetics; POU Domain Factors/metabolism; Water-Electrolyte Balance/genetics
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