GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:19883616
| Citation |
Lee, SJ, Murphy, CT and Kenyon, C (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10:379-91 |
|---|---|
| Abstract |
Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the life span-shortening effect of glucose and that aqp-1 may act cell nonautonomously as a feedback regulator in the insulin/IGF-1-signaling pathway. Insulin downregulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. |
| Links |
PubMed PMC2887095 Online version:10.1016/j.cmet.2009.10.003 |
| Keywords |
Animals; Aquaporin 1/antagonists & inhibitors; Aquaporin 1/genetics; Aquaporin 1/metabolism; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/antagonists & inhibitors; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Down-Regulation; Feedback, Physiological; Gene Knockout Techniques; Glucose/metabolism; Glycerol/metabolism; Insulin/metabolism; Longevity; Receptor, IGF Type 1/physiology; Signal Transduction; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; Transcription Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
See also
References
See Help:References for how to manage references in GONUTS.
