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PMID:19808479
| Citation |
Wagner, S, Hacker, E, Grandi, E, Weber, SL, Dybkova, N, Sossalla, S, Sowa, T, Fabritz, L, Kirchhof, P, Bers, DM and Maier, LS (2009) Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol 2:285-94 |
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| Abstract |
Potassium currents contribute to action potential duration (APD) and arrhythmogenesis. In heart failure, Ca/calmodulin-dependent protein kinase II (CaMKII) is upregulated and can alter ion channel regulation and expression. |
| Links |
PubMed PMC2734104 Online version:10.1161/CIRCEP.108.842799 |
| Keywords |
Action Potentials/physiology; Adenoviridae/genetics; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Female; Heart Failure/physiopathology; Kinetics; Kv1.4 Potassium Channel/physiology; Male; Mice; Mice, Transgenic; Models, Cardiovascular; Myocytes, Cardiac/cytology; Myocytes, Cardiac/physiology; Potassium/metabolism; Potassium Channels/physiology; Rabbits; Shal Potassium Channels/physiology; Transfection; Up-Regulation/physiology |
| edit table |
Significance
Annotations
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