PMID:19646228

Citation	Webb, KJ, Norton, WH, Trümbach, D, Meijer, AH, Ninkovic, J, Topp, S, Heck, D, Marr, C, Wurst, W, Theis, FJ, Spaink, HP and Bally-Cuif, L (2009) Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome Biol. 10:R81
Abstract	Addiction is a pathological dysregulation of the brain's reward systems, determined by several complex genetic pathways. The conditioned place preference test provides an evaluation of the effects of drugs in animal models, allowing the investigation of substances at a biologically relevant level with respect to reward. Our lab has previously reported the development of a reliable conditioned place preference paradigm for zebrafish. Here, this test was used to isolate a dominant N-ethyl-N-nitrosourea (ENU)-induced mutant, no addiction (nad(dne3256)), which fails to respond to amphetamine, and which we used as an entry point towards identifying the behaviorally relevant transcriptional response to amphetamine.
Links	PubMed PMC2728535 Online version:10.1186/gb-2009-10-7-r81
Keywords	Amphetamine/toxicity; Animals; Behavior, Addictive/genetics; Behavior, Animal/drug effects; Behavior, Animal/physiology; Brain/drug effects; Brain/metabolism; Central Nervous System Stimulants/toxicity; DNA-Binding Proteins/genetics; Gene Expression Regulation/drug effects; In Situ Hybridization; Mutation; Reverse Transcriptase Polymerase Chain Reaction; Reward; Transcription Factors/genetics; Transcription, Genetic/genetics; Zebrafish/genetics; Zebrafish/physiology; Zebrafish Proteins/genetics
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Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status

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