PMID:19540327

Citation	Bullmann, T, Holzer, M, Mori, H and Arendt, T (2009) Pattern of tau isoforms expression during development in vivo. Int. J. Dev. Neurosci. 27:591-7
Abstract	Neuronal morphology and axonal growth during development are correlated to specific expression of various microtubule-associated protein tau isoforms. Using RT-PCR and Western blotting we found the unexpected result that the shift from fetal towards adult isoforms does not differ between rat cerebral cortex and cerebellum, two temporally differently developing areas. By immunohistochemistry we observed a cell type specific isoform expression during development and adulthood. The developmental expression of tau isoforms was compared to the appearance of stable microtubules assessed by the immunohistochemical detection of tubulin modifications. The tau isoform shift shows an apparent disconnect to neurogenesis, migration and volume growth, but coincides with the formation of synapses and the appearance of stable microtubules.
Links	PubMed Online version:10.1016/j.ijdevneu.2009.06.001
Keywords	Animals; Cell Differentiation/physiology; Cerebellum/embryology; Cerebellum/metabolism; Cerebellum/ultrastructure; Cerebral Cortex/embryology; Cerebral Cortex/metabolism; Cerebral Cortex/ultrastructure; Female; Immunohistochemistry; Male; Microtubules/metabolism; Microtubules/ultrastructure; Neurogenesis/physiology; Neurons/metabolism; Neurons/ultrastructure; Protein Isoforms/genetics; Protein Isoforms/metabolism; RNA, Messenger/metabolism; Rats; Rats, Inbred WF; Reverse Transcriptase Polymerase Chain Reaction; Synapses/metabolism; Synapses/ultrastructure; Tubulin/metabolism; tau Proteins/genetics; tau Proteins/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:TAU	involved_in	GO:0007420: brain development	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete

References

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